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Isothermal Titration Calorimetry (iTC200 System): iTC200 is used for characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. Enzyme kinetics, assessment of the effect of molecular structural changes on binding mechanisms, assessment of biological activities is also possible. Direct measure of sub-millimolar to nanomolar binding constants (102 to 109 M-1) and measurement of nanomolar to picomolar binding constants (109 to 1012 M-1) using the competitive binding technique.
Manufacturer details: ITC200 MicroCalorimeter
Malvern Instruments Ltd.
Enigma Business Park,Grovewood Road, Malvern,
Worcestershire, WR14 1XZ, UK
Tel: +44 (0)1684 892456 Fax: +44 (0)1684 892789
Date of installation: 10th August, 2012
Isothermal Titration Calorimetry (ITC) is a well-known analytical technique that can effectively used for investigating the thermodynamic properties of the interaction of macromolecules, small molecules etc. The basic principle of ITC is very simple. It basically measures the heat change (that is either released or absorbed) during a biomolecular binding event. The instrument consists of two cells. One is reference cell which contains water or buffer and other one is sample cell which contains the sample. It is important to keep these both cells at exactly the same temperature. The heat sensing devices detect temperature difference between the cells when binding occurs and give feedback to the heaters, which compensate for this difference and return the cells to equal temperature.
Professor in charge: Professor Swagata Dasgupta, Dept. of Chemistry
Professor Amit Kumar Das, Biotechnology Dept.
Professor Ananta Kumar Ghosh, Biotechnology Dept.
Professor Tapas Kumar Maity, Biotechnology Dept.
Professor Rahul Mitra, Department of Metallurgical and Materials Engineering
Professor Adinpunya Mitra, Agricultural and Food Engineering Dept.
Professor Tanmaya Pathak, Dept. of Chemistry
Professor Joykrishna Dey, Dept. of Chemistry
Professor Amit Basak, Dept. of Chemistry
Dr. Koel Chaudhury, School of Medical Science and Technology
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CRF Main Building,
IIT KHARAGPUR 721302
Prof. Swagata Dasgupta, Dept. of Chemistry
Contact No.:- 03222 283306
Mr. Bidhan Singh
Contact no.: 03222 282486